Will steroidal aromatase inhibitors induce rheumatoid arthritis?
نویسندگان
چکیده
منابع مشابه
Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1
Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1) channel, a major pathway in pain transmission and neurogenic inflammation. AIs evoke TRPA1-mediat...
متن کاملSteroidal aromatase inhibitors : Model receptor surfaces and 3 D QSAR
Receptor surfaces have been generated with a training set of 50 steroids active against cytochrome P450 enzyme, aromatase, using the Drug Discovery Workbench (Ceriui). A combination of van der Waals-electrostatic and Wyvill partial-charge force fields together with overlay of 17and 1 3-atoms of the steroid ligand resulted in four different receptor surface models. These models have high conven...
متن کاملCommentary (Harvey): Nonsteroidal and Steroidal Aromatase Inhibitors in Breast Cancer
Hormone-dependent disease is an important and prevalent subtype of breast cancer. It is recognized by the presence of a functional estrogen-receptor apparatus, an indolent clinical course, a greater frequency in older women, and clinical responses to the sequential use of hormonal therapies. Antiestrogens, primarily tamoxifen (Nolvadex), have been the mainstay of hormonal therapy for metastatic...
متن کاملNonsteroidal and steroidal aromatase inhibitors in breast cancer.
Anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin) are members of the third generation of aromatase inhibitors that has now replaced aminoglutethimide (Cytadren), the progestins, and tamoxifen (Nolvadex) as the hormonal therapy of choice in estrogen-receptor-positive, postmenopausal, metastatic breast cancer. This article will review the role of aromatase in the pathogenesis ...
متن کاملProteinase inhibitors in rheumatoid arthritis.
The concentrations of five normally occurring protease inhibitors in serum and synovial fluid were compared in patients with rheumatoid arthritis, osteoarthrosis, and normal controls. The patients with rheumatoid arthritis showed a significant rise in alpha1-antitrypsin, alpha1-antichymotrypsin, and inter-alpha-trypsin inhibitor (in decreasing order) in serum as well as in synovial fluid. In sy...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2006
ISSN: 0003-4967
DOI: 10.1136/ard.2006.066159